Scarlett Gallegos
Doctora en Ciencias Biológicas, área Biología Celular y Molecular
Grados:
Magister en Fisiología Humana
Doctorado en Ciencias Biológicas, área Biología Celular y Molecular
Líneas de investigación
Neuropharmacology,
Synaptic Transmission,
Alcohol consumption,
Aging,
Alzheimer’ Disease
Publicaciones destacadas
Loss of glycine receptors in the nucleus accumbens and ethanol reward in an Alzheimer´s Disease mouse model. Armijo-Weingart L, San Martin L, Gallegos S, Araya A, Konar-Nie M, Fernandez-Pérez E, Aguayo LG. Progress in Neurobiology 237 (2024) 102616. https://doi.org/10.1016/j.pneurobio.2024.102616
Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits. San Martin LS, Armijo-Weingart L, Gallegos S, Araya A, Homanics GE, Aguayo LG. Life Sciences 348 (2024) 122673. https://doi.org/10.1016/j.lfs.2024.122673
GKRP-dependent modulation of feeding behavior by tanycyte-released monocarboxylates. Salgado M, Elizondo-Vega R, Villar PS, Konar M, Gallegos S, Tarifeño-Saldivia E, Luz-Crawford P, Aguayo LG, Araneda RC, Uribe E, García-Robles MÁ. Theranostics. 2022 Jan 3;12(4):1518-1536. doi: 10.7150/thno.66634. eCollection 2022.
Presence of ethanol-sensitive and ethanol-insensitive glycine receptors in the ventral tegmental area and prefrontal cortex in mice. Araya A, Gallegos S, Viveros R, San Martin L, Muñoz B, Harvey RJ, Zeilhofer HU, Aguayo LG. Br J Pharmacol. 2021 Dec;178(23):4691-4707. doi: 10.1111/bph.15649. Epub 2021 Sep 17.
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer’s disease mouse model. Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG. Sci Rep. 2020 Nov 11;10(1):19606. doi: 10.1038/s41598-020-76456-w.
Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor. Gallegos, S., L. San Martin, A. Araya, D. M. Lovinger, G. E. Homanics and L. G. Aguayo (2020). Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 46(3): 528-536.
Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit. San Martin L, Gallegos S, Araya A, Romero N, Morelli G, Comhair J, Harvey RJ, Rigo JM, Brone B, Aguayo LG. Br J Pharmacol. 2020 Sep;177(17):3941-3956. doi: 10.1111/bph.15136. Epub 2020 Jun 30.
Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference. Muñoz, B., S. Gallegos, C. Peters, P. Murath, D. M. Lovinger, G. E. Homanics and L. G. Aguayo (2019). Addiction biology, 25(2), e12726. doi: 10.1111/adb.12726
High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens. Gallegos, S., B. Muñoz, A. Araya and L. G. Aguayo (2019). Neuropharmacology 160: 107773.
Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson’s disease. Gallegos, S., Pacheco, C., Peters, C., Opazo, C. M., & Aguayo, L. G. (2015). Frontiers in neuroscience, 9, 59. doi: 10.3389/fnins.2015.00059
Proyectos destacados
Effects of ethanol on glycine receptors. National Institutes of Health Grant R01AA025718. Fondecyt Regular 1221080 2017-2022.
The nucleus accumbens is a site for early initiation of Alzheimer’s Disease. Fondecyt Regular 1221080. 2022-2026