Gonzalo Enrique Yévenes Crisóstomo

Bioquímico, Universidad de Concepción.

Grados:
– Doctor en Ciencias Biológicas, Universidad de Concepción. Chile, 2002 – 2007
– Investigador Postdoctoral, Instituto de Farmacología y Toxicología, Universidad de Zúrich, Suiza. 2008-2013.

Publicaciones destacadas

“Fast synaptic inhibition in spinal sensory processing and pain control”
Zeilhofer, H.U., Wildner, H., Yevenes, GE.
Physiological Reviews. 92, 193-235, 2012.

“Phosphorylation State-Dependent Modulation of Spinal Glycine Receptors Alleviates Inflammatory Pain”
Acuña MA, Yévenes GE, Ralvenius WT, Benke D, Di Lio A, Lara CO, Muñoz B, Burgos CF, Moraga-Cid G, Corringer PJ, Zeilhofer HU.
Journal of Clinical Investigation. 126:2547-2560, 2016.

“Functional modulation of glycine receptors by the alkaloid gelsemine”
Lara CO, Murath P, Muñoz B, Marileo AM, San Martín L, San Martín VP, Burgos CF, Mariqueo TA, Aguayo LG, Fuentealba J, Godoy P, Guzman L, Yévenes GE.
British Journal of Pharmacology 173:2263-2277, 2016.

“Modulation of glycine receptor single-channel conductance by intracellular phosphorylation”. Moraga-Cid G, San Martín VP, Lara CO, Muñoz B, Marileo AM, Sazo A, Muñoz-Montesino C, Fuentealba J, Castro PA, Guzmán L, Burgos CF, Zeilhofer HU, Aguayo LG, Corringer PJ, Yévenes GE. Scientifics Reports. 16;10(1):4804, 2020.

“Antihyperalgesia by alpha 2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites”
Paul, J., Yévenes GE., D. Benke, A. D. Lio, W. T. Ralvenius, R. Witschi, L. Scheurer, et al.
Neuropsychopharmacology 39 (2): 477-487, 2014.

Proyectos destacados

NUCLEO MILENIO PARA EL ESTUDIO DEL DOLOR (MINUSPAIN), MINISTERIO DE ECONOMÍA.
M. Calvo; C. Coddou; E. Utreras; G. YEVENES; R. Madrid. (2020-2022)
Estado: En ejecución.

CONTRIBUTION OF GLYCINE TO THE PATHOPHYSIOLOGY OF CHRONIC PAIN AND TO THE ANALGESIA INDUCED BY ALLOSTERIC MODULATORS: NOVEL INSIGHTS COMING FROM BRAIN AND MIDBRAIN STRUCTURES WITHIN THE PAIN PATHWAY.
Yevenes, Gonzalo E. (Investigador principal) (2021-2025)
Estado: En ejecución

TARGETING GLYCINE RECEPTORS FOR THE TREATMENT OF CHRONIC PAIN, HYPEREKPLEXIA AND ANXIETY: DEVELOPMENT OF NOVEL MODULATORS BASED ON RECENT STRUCTURAL AND PHARMACOLOGICAL INSIGHTS
Yevenes, Gonzalo E. (Investigador principal); Moraga, Gustavo (Co-investigador) (2017-2021)
Estado: Finalizado

DECIPHERING THE FUNCTIONAL AND STRUCTURAL PROPERTIES OF THE LARGE INTRACELLULAR DOMAIN OF THE PENTAMERIC LIGAND GATED RECEPTORS
Moraga-Cid, Gustavo (Investigador principal); Yevenes, Gonzalo E. (Co-investigador)(2016)
Estado: Finalizado

UNDERSTANDING ALS DISEASE MECHANISMS USING HUMAN INDUCED PLURIPOTENT STEM CELLS DERIVED MOTOR NEURONS (IMNS)
Carrasco, Mónica (Investigador principal); Yevenes, Gonzalo E. (Co-investigador) (2016)
Estado: Finalizado