Loreto San Martin Vásquez
Doctora en Ciencias Biológicas
Grados:
Doctora en Ciencias Biológicas, área Biología Celular y Molecular
Líneas de investigación
Alcohol consumption, Ligand-gated ion channels, Synaptic transmission, Alzheimer’s disease, Limbic system
Publicaciones destacadas
Loreto S San Martin; Lorena Armijo-Weingart; Scarlet Gallegos; Anibal Araya; Gregg E., Homanics, Luis G. Aguayo. Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits. Life Sciences 348 (2024) 122673 (https://doi.org/10.1016/j.lfs.2024.122673).
Lorena Armijo Weingart, Loreto San Martin, Scarlet Gallegos, Anibal Araya, Macarena Konar-Nie, Eduardo Fernandez-Pérez, Luis G. Aguayo. Loss of glycine receptors in the nucleus accumbens and ethanol reward in an Alzheimer´s Disease mouse model. Progress in Neurobiology 237 (2024) 102616 (https://doi.org/10.1016/j.pneurobio.2024.102616).
San Martin LS, Armijo-Weingart L, Araya A, Yévenes GE, Harvey RJ, Aguayo LG. Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens (2021). Frontiers in Molecular Neuroscience, DOI: 10.3389/fnmol.2021.756607.
Araya, A., Gallegos, S., Viveros, R., San Martin, L., Muñoz, B., Harvey, RJ., Zeilhofer, HU. and Aguayo, LG. Presence of ethanol sensitive and insensitive glycine receptors in the ventral tegmental area and prefrontal cortex in mice (2021). British journal of pharmacology, DOI: 10.1111/bph.15649.
Vásquez P.A., San Martín L., Argel Y., Riquelme C., Torres J., Vidal F., Cayuman F., Castro P., Fuentealba J., Moraga-Cid G., Yevenes G., Jin C., Jiménez V.A., Guzmán L. (2020). Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers. Journal of Chemical Information and Modeling, 60(12): 6634-6641. doi: 10.1021/acs.jcim.0c00943.
San Martin, L., Gallegos, S., Araya, A., Romero, N., Morelli, G., Comhair, J., Harvey, R. J., Rigo, J. M., Brone, B., & Aguayo, L. G. (2020). Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit. British journal of pharmacology, 177(17):3941-3956.
Gallegos, S., San Martin, L., Araya, A., Lovinger, D. M., Homanics, G. E., & Aguayo, L. G. (2020). Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor. Neuropsychopharmacology, 46(3): 528-536.
San Martin L, Cerda F, Jin C, Jimenez V, Yevenes GE, Hernandez T, Nova D, Fuentealba J, Aguayo LG, Guzman L. (2016). Reversal of ethanol-induced intoxication by a novel modulator of G protein potentiation of the glycine receptor. The Journal of Biological Chemistry, 291(36): 18791-8.
Lara, C., Murath, P., Muñoz, B., Marileo, A., San Martín, L., San Martín, V., Burgos, C., Mariqueo, T., Aguayo, L., Fuentealba, J., Godoy, P., Guzmán, J., Yévenes, G. (2016). Functional modulation of glycine receptors by the alkaloid gelsemine. British Journal of Pharmacology, 173(14): 2263-77
Sánchez A, Yévenes GE, San Martin L, Burgos CF, Moraga-Cid G, Harvey RJ, Aguayo LG. (2015). Control of ethanol sensitivity of the glycine receptor alpha3 subunit by transmembrane 2, the intracellular splice cassette and C-terminal domains. Journal of Pharmacology and Experimental Therapeutics, 353(1), 80-90.
Mariqueo TA, Agurto A, Muñoz B, San Martin L, Coronado C, Fernández-Pérez EJ, Murath P, Sánchez A, Homanics GE, Aguayo LG. (2014). Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons. Journal of Neurophysiology, 111(10): 1940-1948.
San Martin L, Cerda F, Jimenez V, Fuentealba J, Muñoz B, Aguayo LG, Guzman L. (2012). Inhibition of the ethanol-induced potentiation of alpha1 glycine receptor by a small peptide that interferes with Gbetagamma binding. The Journal of Biological Chemistry, 287(48): 40713-40721.
Castro PA, Figueroa M, Yevenes GE, San Martin LS, Aguayo LG. (2012). The basic property of Lys385 is important for potentiation of the human alpha1 glycine receptor by ethanol. Journal of Pharmacology and Experimental Therapeutics, 340(2): 339-349.
Proyectos destacados
- The nucleus accumbens is a site for early initiation of Alzheimer’s Disease. Fondecyt Regular 1221080. 2022-2026 – Investigadora asociada.
- Effects of ethanol on glycine receptors. National Institutes of Health Grant R01AA025718. Fondecyt Regular 1221080 2017-2022 – Investigadora asociada.