Luis Gerardo Aguayo Hernández

Director

Grados:
Doctorado en Farmacología, UNIVERSITY OF MARYLAND. Estados Unidos, 1985. Senior Staff Fellow, National Institute of Health (NIH).

Publicaciones destacadas

Loss of glycine receptors in the nucleus accumbens and ethanol reward in an Alzheimer´s Disease mouse model. Armijo-Weingart L, San Martin L, Gallegos S, Araya A, Konar-Nie M, Fernandez-Pérez E, Aguayo LG. Progress in Neurobiology 237 (2024) 102616.  https://doi.org/10.1016/j.pneurobio.2024.102616

Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits. San Martin LS, Armijo-Weingart L, Gallegos S, Araya A, Homanics GE, Aguayo LG. Life Sciences 348 (2024) 122673. https://doi.org/10.1016/j.lfs.2024.122673

Molecular Pharmacology of Gelsemium Alkaloids on Inhibitory Receptors. Marileo AM, Lara CO, Sazo A, Contreras OV, González G, Castro PA, Aguayo LG, Moraga-Cid G, Fuentealba J, Burgos CF, Yévenes GE. Int. J. Mol. Sci. 2024, 25(6), 3390; https://doi.org/10.3390/ijms25063390 

Neurocytotoxicity of imidacloprid- and acetamiprid-based comercial insecticides over the differentiation of SH-SY5Y neuroblastoma cells. Ramirez-Cando LJ, Guzmán-Vallejos MS, Aguayo LG, Vera-Erazo FD, Ballaz SJ. Heliyon 9 (2023) e15840. https://doi.org/10.1016/j.heliyon.2023.e15840

Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine. Marileo AM, Gavilán J, San Martín VP, Lara CO, Sazo A, Muñoz-Montesino C, Castro PA, Burgos CF, Leiva-Salcedo E, Aguayo LG, Moraga-Cid G, Fuentealba J, Yévenes GE. Front. Mol. Neurosci. 15:1083189. https://doi.org/10.3389/fnmol.2022.1083189

Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice. Araya A, Gallegos S, Maldonado A, Rivera-Meza M, Chandra R, Lobo MK, Aguayo LG. Neuropsychopharmacol. 48, 1367–1376 (2023). https://doi.org/10.1038/s41386-022-01459-2

Aging in nucleus accumbens and its impact on alcohol use disorders. Konar-Nié M, Guzman-Castillo A, Armijo-Weingart L, Aguayo LG. Alcohol 107 (2023) 73-90. https://doi.org/10.1016/j.alcohol.2022.08.004

GKRP-dependent modulation of feeding behavior by tanycyte-released monocarboxylates. Salgado M, Elizondo-Vega R, Villar PS, Konar M, Gallegos S, Tarifeño-Saldivia E, Luz-Crawford P, Aguayo LG, Araneda RC, Uribe E, García-Robles MÁ. Theranostics. 2022 Jan 3;12(4):1518-1536. doi: 10.7150/thno.66634. eCollection 2022.

The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine.
Ramirez AE, Fernández-Pérez EJ, Olivos N, Burgos CF, Boopathi S, Armijo-Weingart L, Pacheco CR, González W, Aguayo LG. Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253.

Modulatory Actions of the Glycine Receptor β Subunit on the Positive Allosteric Modulation of Ethanol in α2 Containing Receptors. Muñoz B, Mariqueo T, Murath P, Peters C, Yevenes GE, Moraga-Cid G, Peoples RW, Aguayo LG. Front Mol Neurosci. 2021 Nov 18;14:763868. doi: 10.3389/fnmol.2021.763868. eCollection 2021.

Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens. San Martin LS, Armijo-Weingart L, Araya A, Yévenes GE, Harvey RJ, Aguayo LG. Front Mol Neurosci. 2021 Oct 22;14:756607. doi: 10.3389/fnmol.2021.756607. eCollection 2021.

Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers. Fernandez-Perez EJ, Muñoz B, Bascuñan DA, Peters C, Riffo-Lepe NO, Espinoza MP, Morgan PJ, Filippi C, Bourboulou R, Sengupta U, Kayed R, Epsztein J, Aguayo LG. Aging Cell. 2021 Sep;20(9):e13455. doi: 10.1111/acel.13455. Epub 2021 Aug 19.

Presence of ethanol-sensitive and ethanol-insensitive glycine receptors in the ventral tegmental area and prefrontal cortex in mice. Araya A, Gallegos S, Viveros R, San Martin L, Muñoz B, Harvey RJ, Zeilhofer HU, Aguayo LG. Br J Pharmacol. 2021 Dec;178(23):4691-4707. doi: 10.1111/bph.15649. Epub 2021 Sep 17.

Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer’s Disease. Toledo JP, Fernández-Pérez EJ, Ferreira IL, Marinho D, Riffo-Lepe NO, Pineda-Cuevas BN, Pinochet-Pino LF, Burgos CF, Rego AC, Aguayo LG. Front Neurosci. 2021 Feb 19;15:617821. doi: 10.3389/fnins.2021.617821. eCollection 2021.

Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration. González-Sanmiguel J, Schuh CMAP, Muñoz-Montesino C, Contreras-Kallens P, Aguayo LG, Aguayo S. Cells. 2020 Nov 13;9(11):2476. doi: 10.3390/cells9112476.

Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer’s disease mouse model. Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG. Sci Rep. 2020 Nov 11;10(1):19606. doi: 10.1038/s41598-020-76456-w.

Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit. San Martin L, Gallegos S, Araya A, Romero N, Morelli G, Comhair J, Harvey RJ, Rigo JM, Brone B, Aguayo LG. Br J Pharmacol. 2020 Sep;177(17):3941-3956. doi: 10.1111/bph.15136. Epub 2020 Jun 30.

Presence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. Förstera B, Muñoz B, Lobo MK, Chandra R, Lovinger DM, Aguayo LG. J Physiol. 2017 Aug 1;595(15):5285-5300. doi: 10.1113/JP273767. Epub 2017 Jun 23.

Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer’s disease. Sepúlveda FJ, Fierro H, Fernandez E, Castillo C, Peoples RW, Opazo C, Aguayo LG. Neurobiol Aging. 2014 Mar;35(3):472-81. doi: 10.1016/j.neurobiolaging.2013.08.035. Epub 2013 Oct 8.

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide. Peters C, Fernandez-Perez EJ, Burgos CF, Espinoza MP, Castillo C, Urrutia JC, Streltsov VA, Opazo C, Aguayo LG. Neurobiol Aging. 2013 Dec;34(12):2805-14. doi: 10.1016/j.neurobiolaging.2013.06.001. Epub 2013 Jul 12.

Proyectos destacados

The nucleus accumbens is a site for early initiation of Alzheimer’s Disease. Fondecyt Regular 1221080. 2022-2026

Novel anti neurodegenerative molecules that block multiple steps in the amyloid cascade. Aguayo Luis. Fondecyt 2018-2022.

Molecular determinants for neurotoxic actions of a-Beta peptide. Autores: Aguayo, Luis; Sanchez, Susana. Fondecyt 2014-2017.

Effects of ethanol on glycine receptors. National Institutes of Health Grant R01AA025718. Fondecyt Regular 1221080 2017-2022.

G protein modulation of glycine receptor function and ethanol action. Autores: Homanics, Gregg E.; Aguayo, Luis G. National Institute of Health. 2008-2010.

Potentiation of the glycine receptor by ethanol. Autores: Aguayo, Luis G. National Institute of Health. (2008)