Gonzalo Enrique Yévenes Crisóstomo

Bioquímico, Universidad de Concepción.

Grados:
– Doctor en Ciencias Biológicas, Universidad de Concepción. Chile, 2002 – 2007
– Investigador Postdoctoral, Instituto de Farmacología y Toxicología, Universidad de Zúrich, Suiza. 2008-2013.

Publicaciones destacadas

Gavilan, J., Panes-Fernández, J., Araya, A., Pérez-Manríquez, C., Becerra, J., Varas, P., … & Fuentealba, J. (2026). Unraveling the neuroprotective mechanisms of elephant black garlic extract against beta amyloid peptide-induced neurotoxicity. Frontiers in Nutrition, 12, 1725284. Doi: 10.3389/fnut.2025.1725284

Lara, C. O., Burgos, C. F., Fariña-Oliva, K., Marileo, A. M., Martín, V. P. S., Flaig, D., … & Yévenes, G. E. (2025). Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide. Scientific Reports, 15(1), 5515. Doi: 10.1038/s41598-025-90209-7

Panes-Fernández, J., Marileo, A. M., Espinoza-Rubilar, N., Meza, M. E., Salgado-Martínez, B. A., Gaete-Riquelme, K., … & Yévenes, G. E. (2025). The Alkaloid Gelsemine Reduces Aß Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme. Plants, 14(10), 1556. Doi: 10.3390/plants14101556

Meza, M. E., Ramirez-Molina, O., Flores, O., Fariña-Oliva, K., Godoy, P. A., Fuentealba, J., & Yévenes, G. E. (2026). Neuronal ion channel modulation by Drimys winteri compounds: Opening a new chemical space to neuropharmacology. Neural Regeneration Research, 21(4), 1373-1382. Doi: 10.4103/NRR.NRR-D-24-01194

Millar-Obreque, C., González-Muñoz, V., Marileo, A. M., Salgado-Martínez, B., Gaete-Riquelme, K., Ramírez-Molina, O., … & Burgos, C. F. (2025). In Silico Characterization of Gelsemium Compounds as Glycine Receptor Ligands. Compounds, 5(4), 40. Doi: 10.3390/compounds5040040

Marileo, A. M., Lara, C. O., Sazo, A., Contreras, O. V., González, G., Castro, P. A., … & Yévenes, G. E. (2024). Molecular Pharmacology of Gelsemium Alkaloids on Inhibitory Receptors. International Journal of Molecular Sciences, 25(6), 3390. Doi: 10.3390/ijms25063390

Tovar, L. M., Burgos, C. F., Yévenes, G. E., Moraga-Cid, G., Fuentealba, J., Coddou, C., … & Castro, P. A. (2023). Understanding the Role of ATP Release through Connexins Hemichannels during Neurulation. International Journal of Molecular Sciences, 24(3), 2159. Doi: 10.3390/ijms24032159

Marileo, A. M., Gavilán, J., San Martín, V. P., Lara, C. O., Sazo, A., Muñoz-Montesino, C., … & Yévenes, G. E. (2023). Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine. Frontiers in Molecular Neuroscience, 15, 1083189. Doi: 10.3389/fnmol.2022.1083189

Panes-Fernandez, J., Godoy, P. A., Gavilan, J., Ramírez-Molina, O., Burgos, C. F., Marileo, A., … & Fuentealba, J. (2023). TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer’s disease. Biomedicine & Pharmacotherapy, 162, 114596. Doi: 10.1016/j.biopha.2023.114596

Castro, P. A., Pinto-Borguero, I., Yévenes, G. E., Moraga-Cid, G. & Fuentealba, J. (2022). Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets. Frontiers in Pharmacology, 13, 948412. Doi: 10.3389/fphar.2022.948412

San Martín, V. P., Sazo, A., Utreras, E., Moraga-Cid, G., & Yévenes, G. E. (2022). Glycine Receptor Subtypes and Their Roles in Nociception and Chronic Pain. Frontiers in Molecular Neuroscience, 15, 848642. Doi: 10.3389/fnmol.2022.848642

Petermann, A. B., Reyna-Jeldes, M., Ortega, L., Coddou, C., & Yévenes, G. E. (2022). Roles of the Unsaturated Fatty Acid Docosahexaenoic Acid in the Central Nervous System: Molecular and Cellular Insights. International Journal of Molecular Sciences, 23(10), 5390. Doi: 10.3390/ijms23105390

Zeilhofer, H. U., Werynska, K., Gingras, J., & Yévenes, G. E. (2021). Glycine Receptors in Spinal Nociceptive Control-An Update. Biomolecules, 11(6), 846. Doi: 10.3390/biom11060846

San Martin, L. S., Armijo-Weingart, L., Araya, A., Yévenes, G. E., Harvey, R. J., & Aguayo, L. G. (2021). Contribution of GlyR a3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens. Frontiers in Molecular Neuroscience, 14, 756607. Doi: 10.3389/fnmol.2021.756607

Muñoz, B., Mariqueo, T., Murath, P., Peters, C., Yevenes, G. E., Moraga-Cid, G., … & Aguayo, L. G. (2021). Modulatory actions of the glycine receptor ß subunit on the positive allosteric modulation of ethanol in a2 containing receptors. Frontiers in Molecular Neuroscience, 14(18), 763868. Doi: 10.3389/fnmol.2021.763868

Moraga-Cid, G., San Martín, V. P., Lara, C. O., Muñoz, B., Marileo, A. M., Sazo, A., … & Burgos, C. F. (2020). Modulation of glycine receptor single-channel conductance by intracellular phosphorylation. Scientific Reports, 10(1), 4804. Doi: 10.1038/s41598-020-61677-w

Lara, C. O., Burgos, C. F., Moraga-Cid, G., Carrasco, M. A. and Yévenes, G. E. (2020). Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain. Frontiers in Pharmacology, 11, 167. Doi: 10.3389/fphar.2020.00167

Panes, J. D., Godoy, P. A., Silva-Grecchi, T., Celis, M. T., Ramirez-Molina, O., Gavilan, J., … & Guzmán, L. (2020). Changes in PGC-1a/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model. Frontiers in Pharmacology, 11, 709. Doi: 10.3389/fphar.2020.00709

Benavides-Rivas, C., Tovar, L. M., Zúñiga, N., Pinto-Borguero, I., Retamal, C., Yévenes, G. E., … & Bascuñán-Godoy, L. (2020). Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects. Frontiers in Pharmacology, 11, 900. Doi: 10.3389/fphar.2020.00900

Munoz-Montesino, C., Burgos, C. F., Lara, C. O., Riquelme, C. R., Flaig, D., San Martin, V. P., … & Yévenes, G. E. (2020). Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Frontiers in Pharmacology, 11, 1143. Doi: 10.3389/fphar.2020.01143

Vásquez, P. A., San Martín, L., Argel, Y., Riquelme, C., Torres, J., Vidal, F., … & Guzmán, L. (2020). Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers. Journal of Chemical Information and Modeling, 60(12), 6634-6641. Doi: 10.1021/acs.jcim.0c00943

Yévenes, G. E., Bravo, J. A., Díaz-Araya, G., Sotomayor-Zárate, R., Fiedler, J. L., Reyes-Parada, M., & Fuentealba, J. (2020). celebrating 40 years of the chilean society of pharmacology. Frontiers in Pharmacology, 11, 623195. Doi: 10.3389/fphar.2020.623195

Gavilan, J., Mennickent, D., Ramirez-Molina, O., Triviño, S., Perez, C., Grecchi, T. S., … & Martin, V. S. (2018). 17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-ß Toxicity by Nicotinic Acetylcholine Receptors. Journal of Alzheimer’s Disease, 67(1), 343-356. doi: 10.3233/JAD-180945

Yevenes, G. E., San Martin, V. P., Burgos, C. F., Lara, C. O., Marileo, A. M., Sazo, A., … & Moraga-Cid, G. (2019). Inhibitory actions of tropeines on the alpha3 glycine receptor function. Frontiers in Pharmacology, 10, 331. doi: 10.3389/fphar.2019.00331

Lara, C. O., Burgos, C. F., Silva-Grecchi, T., Munoz-Montesino, C., Aguayo, L. G., Fuentealba, J., … & Moraga-Cid, G. (2019). Large intracellular domain-dependent effects of Positive Allosteric Modulators on Glycine receptors. ACS Chemical Neuroscience, 10(5), 2551-2559. doi: 10.1021/acschemneuro.9b00050

Sáez-Orellana, F., Fuentes-Fuentes, M. C., Godoy, P. A., Silva-Grecchi, T., Panes, J. D., Guzmán, L., … & Fuentealba, J. (2018). P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer’s disease. Neuropharmacology, 128, 366-378. doi: 10.1016/j.neuropharm.2017.10.027

Zeilhofer, H. U., Acuña, M. A., Gingras, J., & Yévenes, G. E. (2018). Glycine receptors and glycine transporters: targets for novel analgesics? Cellular and Molecular Life Sciences, 75(3), 447-465. doi:10.1007/s00018-017-2622-x

Vidal, F., Vásquez, P., Cayumán, F. R., Díaz, C., Fuentealba, J., Aguayo, L. G., … & Guzmán, L. (2018). Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization. Nanomaterials, 8(1). doi:10.3390/nano8010007

Muñoz, B., Yevenes, G. E., Förstera, B., Lovinger, D. M., & Aguayo, L. G. (2018). Presence of inhibitory glycinergic transmission in medium spiny neurons in the nucleus accumbens. Frontiers in Molecular Neuroscience, 11, 228. doi: 10.3389/fnmol.2018.00228

Diaz, C., Benitez, C., Vidal, F., Barraza, L. F., Jiménez, V. A., Guzman, L., … & Alderete, J. B. (2018). Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers. Nanomedicine: Nanotechnology, Biology and Medicine, 14(7), 2227-2234. doi: 10.1016/j.nano.2018.07.005

“Fast synaptic inhibition in spinal sensory processing and pain control”
Zeilhofer, H.U., Wildner, H., Yevenes, GE.
Physiological Reviews. 92, 193-235, 2012.

“Phosphorylation State-Dependent Modulation of Spinal Glycine Receptors Alleviates Inflammatory Pain”
Acuña MA, Yévenes GE, Ralvenius WT, Benke D, Di Lio A, Lara CO, Muñoz B, Burgos CF, Moraga-Cid G, Corringer PJ, Zeilhofer HU.
Journal of Clinical Investigation. 126:2547-2560, 2016.

“Functional modulation of glycine receptors by the alkaloid gelsemine”
Lara CO, Murath P, Muñoz B, Marileo AM, San Martín L, San Martín VP, Burgos CF, Mariqueo TA, Aguayo LG, Fuentealba J, Godoy P, Guzman L, Yévenes GE.
British Journal of Pharmacology 173:2263-2277, 2016.

“Modulation of glycine receptor single-channel conductance by intracellular phosphorylation”. Moraga-Cid G, San Martín VP, Lara CO, Muñoz B, Marileo AM, Sazo A, Muñoz-Montesino C, Fuentealba J, Castro PA, Guzmán L, Burgos CF, Zeilhofer HU, Aguayo LG, Corringer PJ, Yévenes GE. Scientifics Reports. 16;10(1):4804, 2020.

“Antihyperalgesia by alpha 2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites”
Paul, J., Yévenes GE., D. Benke, A. D. Lio, W. T. Ralvenius, R. Witschi, L. Scheurer, et al.
Neuropsychopharmacology 39 (2): 477-487, 2014.

Proyectos destacados

Metabotropic glycine receptors (GPR158) in nociception and chronic pain: regulatory roles of GPR158 on inhibitory neurotransmission and neural excitability in the pain pathway. FONDECYT 1250856. Investigador Principal. 2025–2029. (En ejecución).

Regulation of inhibitory synapses by neuroactive steroids. INSERM Francia DHNS-INSERM U 119. Coinvestigador. 2025–2029. (En ejecución).

Role of p75 neurotrophin receptor to nociception and chronic pain. VRID 2023000763INI. Coinvestigador. 2023–2025. (Cerrado).

Regulation and adaptation of inhibitory synapses by neuroactive steroids. Cooperación Internacional ECOS210017. Investigador Principal. 2022–2024. (Cerrado).

NUCLEO MILENIO PARA EL ESTUDIO DEL DOLOR (MINUSPAIN), MINISTERIO DE ECONOMÍA.
M. Calvo; C. Coddou; E. Utreras; G. YEVENES; R. Madrid. (2020-2022)
Estado: En ejecución.

CONTRIBUTION OF GLYCINE TO THE PATHOPHYSIOLOGY OF CHRONIC PAIN AND TO THE ANALGESIA INDUCED BY ALLOSTERIC MODULATORS: NOVEL INSIGHTS COMING FROM BRAIN AND MIDBRAIN STRUCTURES WITHIN THE PAIN PATHWAY.
Yevenes, Gonzalo E. (Investigador principal) (2021-2025)
Estado: En ejecución

TARGETING GLYCINE RECEPTORS FOR THE TREATMENT OF CHRONIC PAIN, HYPEREKPLEXIA AND ANXIETY: DEVELOPMENT OF NOVEL MODULATORS BASED ON RECENT STRUCTURAL AND PHARMACOLOGICAL INSIGHTS
Yevenes, Gonzalo E. (Investigador principal); Moraga, Gustavo (Co-investigador) (2017-2021)
Estado: Finalizado

DECIPHERING THE FUNCTIONAL AND STRUCTURAL PROPERTIES OF THE LARGE INTRACELLULAR DOMAIN OF THE PENTAMERIC LIGAND GATED RECEPTORS
Moraga-Cid, Gustavo (Investigador principal); Yevenes, Gonzalo E. (Co-investigador)(2016)
Estado: Finalizado

UNDERSTANDING ALS DISEASE MECHANISMS USING HUMAN INDUCED PLURIPOTENT STEM CELLS DERIVED MOTOR NEURONS (IMNS)
Carrasco, Mónica (Investigador principal); Yevenes, Gonzalo E. (Co-investigador) (2016)
Estado: Finalizado