laguayo@udec.cl
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Luis Gerardo Aguayo Hernández

Director

Grados:
Doctorado en Farmacología, UNIVERSITY OF MARYLAND. Estados Unidos, 1985. Senior Staff Fellow, National Institute of Health (NIH).

Líneas de investigación

Neurodegeneration,
Neuropharmacology,
Synaptic Transmission,
Alcoholism,
Alzheimer’ Disease,

Publicaciones destacadas

Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer’s disease mouse model. Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG. Sci Rep. 2020 Nov 11;10(1):19606. doi: 10.1038/s41598-020-76456-w.

Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit.
San Martin L, Gallegos S, Araya A, Romero N, Morelli G, Comhair J, Harvey RJ, Rigo JM, Brone B, Aguayo LG. Br J Pharmacol. 2020 Sep;177(17):3941-3956. doi: 10.1111/bph.15136. Epub 2020 Jun 30.

Presence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. Förstera B, Muñoz B, Lobo MK, Chandra R, Lovinger DM, Aguayo LG. J Physiol. 2017 Aug 1;595(15):5285-5300. doi: 10.1113/JP273767. Epub 2017 Jun 23.

Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer’s disease. Sepúlveda FJ, Fierro H, Fernandez E, Castillo C, Peoples RW, Opazo C, Aguayo LG.
Neurobiol Aging. 2014 Mar;35(3):472-81. doi: 10.1016/j.neurobiolaging.2013.08.035. Epub 2013 Oct 8.

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide. Peters C, Fernandez-Perez EJ, Burgos CF, Espinoza MP, Castillo C, Urrutia JC, Streltsov VA, Opazo C, Aguayo LG. Neurobiol Aging. 2013 Dec;34(12):2805-14. doi: 10.1016/j.neurobiolaging.2013.06.001. Epub 2013 Jul 12.

Proyectos destacados

NOVEL ANTI NEURODEGENERATIVE MOLECULES THAT BLOCK MULTIPLE STEPS IN THE AMYLOID CASCADE. Aguayo Luis. Fondecyt 2018-2022.

MOLECULAR DETERMINANTS FOR NEUROTOXIC ACTIONS OF ABETA PEPTIDE
AUTORES: Aguayo, Luis; Sanchez, Susana. Fondecyt 2014-2017.

EFFECTS OF ETHANOL ON GLYCINE RECEPTORS
AUTORES: Luis G. Aguayo. National Institute of Health 2017-2022.

G PROTEIN MODULATION OF GLYCINE RECEPTOR FUNCTION AND ETHANOL ACTION
AUTORES: Homanics, Gregg E.; Aguayo, Luis G. National Institute of Health. 2008-2010.

POTENTIATION OF THE GLYCINE RECEPTOR BY ETHANOL
AUTORES: Aguayo, Luis G. National Institute of Health. (2008)

Teléfono: 56412203344
Email: nepsamudec@udec.cl

COLABORADORES

NEPSAM, UNIVERSIDAD DE CONCEPCIÓN/CONCEPCIÓN - CHILE

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